About Us
CNS×3 is a pioneering multi- and interdisciplinary research center dedicated to advancing personalized brain-on-chip models for the study of human brain diseases.
With eight academic partners and two industry partners, our mission is to accelerate the discovery of therapeutic solutions for CNS disorders,
which pose significant health burdens worldwide. Led by Uppsala University, CNS×3 combines expertise in bioengineering, molecular medicine, and computational biology
to push the frontiers of CNS research.
Collaborators & Partners
Our collaborative team unites researchers from renowned institutions, including experts from
Uppsala University,
Linköping University, and
Chalmers University of Technology.
Industry partners Navinci and Key2Brain bring essential technology and insights,
enabling advanced measurement capabilities and therapeutic delivery models crucial for CNS research.
Our Research
Key Focus Areas
- Advanced Organoid Modeling: Our team develops vascularized, brain-specific organoids that replicate human CNS environments. Using cutting-edge techniques,
we integrate vascular cells and develop regional models to enhance the study of specific CNS conditions.
- Therapeutic Discovery: Leveraging biobank-sourced patient samples, we focus on discovering treatments for diseases such as pediatric brain tumors, glioblastoma,
and vascular malformations.
- Algorithm-Guided Treatment Regimens: We use AI-driven methodologies to customize therapeutic regimens for individuals, allowing for real-time, patient-centered adjustments in treatment protocols.
Meet the Team
Principal Investigators
- Sven Nelander, Ph.D. - Professor of Cancer Systems Biology, Uppsala University. Scientific Director CNSx3.
- Peetra Magnusson, Ph.D. - Associate Professor, Uppsala University, Managing Director CNSx3, Research School Director Data Driven Life Science (DDLS)
- Maria Tenje, Ph.D. - Professor of Microsystem Technology, Uppsala University
- Daniel Aili, Ph.D. - Professor of Biomaterials, Linköping University
- Fredrik Swartling, Ph.D. - Senior Lecturer of Pediatric Brain Tumor Biology, Uppsala University
- Rebecka Jörnsten, Ph.D. - Professor of Applied Mathematics and Statistics, University of Gothenburg
- Niklas Dahl, M.D., Ph.D. - Professor of Clinical Genetics, Uppsala University Hospital
- Philip Gerlee, Ph.D. - Professor of Biomathematics, Chalmers University of Technology
Governing Board
- Hillevi Englund, Ph.D. - UU Innovation, Chair
- Jana Bergholz, Ph.D. - Patient Representative, CASE (Cavernöst Angiom Sverige)
- Agata Zeba Wicher, Ph.D. - Chief Product and Science Officer, Navinci Diagnostics
- Elisabet Sjöström, Ph.D. - CEO, Key2Brain AB
- Bettina Ryll, Ph.D. - Melanoma Patient Network Europe
- Sven Nelander, Ph.D. - Professor, Uppsala University
- Daniel Aili, Ph.D. - Professor, Linköping University
- Peetra Magnusson, Ph.D. - Associate Professor, Uppsala University
Scientific Advisory Board
- Simon Tavaré, Ph.D. - Founding Director, Irving Institute for Cancer Dynamics, Columbia University
- Mimi Bandopadhayay, M.D., Ph.D. - Director, Dana Farber Cancer Institute Low-Grade Glioma Program; Associate Professor, Harvard Medical School and Broad Institute of MIT and Harvard
- Nilsson Gauthier, Ph.D. - Associate Professor of Mechano-Oncology, IFOM Institute of Molecular Oncology, Milan
- Kristina Haase, Ph.D. - Research Group Leader, Tissue Biology and Disease Modeling, EMBL Barcelona
Get Involved
CNS×3 is hiring! We are looking for Ph.D. students, research assistants, and postdocs. Information will be available here soon. You may also want to contact us at info@cnsx3.se for further details.
Partner with Us
We welcome collaboration inquiries from academic institutions, industry partners, and other research centers. For collaboration inquiries, please
contact us.